Anti-Sperm Antibodies

Dr. Arun Kumar

Anti-Sperm antibodies are fight against sperms. They occur when the immune system assumes the sperm to be an invader of the body and hence fights to damage or destroy the sperm cells in the semen. It does not always lead to infertility issues but can be cured.
Main Causes
  • Testicular infection/torsion/injuries lead to an immune response when sperm merges with blood or comes in contact with the blood.
  • Anti-Sperm antibodies are produced after undergoing surgeries like a vasectomy.
  • Women’s bodies can generate anti-sperm antibodies when they have an allergic reaction to semen. The antibodies present in a woman’s vagina would kill the sperm. But the case is rare. Hence, the doctors don’t know the exact reason behind these antibodies.
Testing: A necessity?
If your sexual life doesn’t lead you towards pregnancy, doctors recommend fertility tests. Anti-sperm antibodies tests are one among them.
  • Males are tested with the immunobead test on the sperm. Men need to masturbate to provide a sample of semen. Other tests include the antiglobulin reaction test performed on the direct blood.
  • Females are tested with the sperm immobilization test with a blood sample. On rare occasions, women are tested with cervical mucus for detecting anti-sperm antibodies.
Treatment: A possibility?
Some people believe that there is no point in testing for anti-sperm antibodies. They say that there is no single cure to help people having antibodies, want to have children. Yet, there are methods for helping people with infertility due to the production of anti-sperm antibodies.
  • Doctors might provide medication to reduce the body’s immune response. This way could lead to the reduction of antibodies and might increase the chances of the females getting pregnant.
  • Intrauterine Insemination is the most plausible way to make females get pregnant, those who mourn from infertility caused due to the antibodies.
Doctors try to inject sperm directly into the uterus. It makes the sperm contact with the egg and prevents the interaction of anti-sperm antibodies with the sperm, in cervical mucus.

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