Dr. Aruna Ashok MBBS, MS OG, DNB OG
- Clinical Director
Aruna Ashok | 04 March 2023
Down syndrome, a genetic disorder caused by the presence of an extra copy of chromosome 21, can result in developmental delays, intellectual disabilities, and various health issues. With advances in reproductive technology, it is now possible to identify and reduce the risk of Down syndrome before delivery using Pre implantation Genetic Testing (PGT). In this article, we will discuss how PGT can help eradicate Down syndrome for your baby before delivery, and the role of A4 Fertility Clinic in offering this service.
PGT is a cutting-edge technique used in conjunction with in vitro fertilization (IVF) to screen embryos for specific genetic conditions, such as Down syndrome before they are implanted in the uterus. This testing allows couples with a high risk of passing on genetic disorders to select healthy embryos for transfer, increasing the chances of a successful pregnancy and healthy baby.
PGT for Down syndrome, also known as PGT-A (Pre implantation Genetic Testing for Aneuploidy), involves screening embryos for the presence of an extra copy of chromosome 21. During the IVF process, eggs are retrieved from the woman's ovaries and fertilized with sperm in a laboratory. Once the embryos reach the blastocyst stage (typically five to six days after fertilization), a few cells are carefully removed from each embryo and analysed for chromosomal abnormalities.
Embryos found to have a normal number of chromosomes can be selected for transfer to the woman's uterus, while those with an extra copy of chromosome 21 can be excluded. This process significantly reduces the risk of having a baby with Down syndrome.
Reduced risk : By selecting embryos without the extra chromosome, PGT reduces the likelihood of having a child with Down syndrome and the associated health complications. Increased success rates: PGT can improve the chances of a successful pregnancy, as chromosomal normal embryos are more likely to implant and develop healthily. Based on the results of PGT, couples can make informed decisions regarding their family planning.
Emotional and ethical concerns: Some couples may struggle with the decision to use PGT, as it involves selecting embryos based on their genetic makeup. It is essential to discuss these concerns with a healthcare professional or counsellor before deciding on PGT.
Cost: PGT can be expensive, as it requires additional laboratory testing and analysis beyond standard IVF procedures. Some insurance plans may not cover the costs of PGT. False positives or negatives: Although PGT is highly accurate, there is a small chance of false-positive or false-negative results. It is important to discuss these possibilities with your fertility specialist.
At A4 Fertility Clinic, we recognize the significance of offering comprehensive fertility services, such as PGT for Down syndrome. Our team of highly trained specialists is dedicated to providing personalized care and support throughout your pregnancy.
Genetic counselling: Our genetic counsellor can help you understand the benefits, drawbacks, and limitations of PGT and guide you through the decision-making process. Our state-of-the-art laboratory facilities allow us to perform PGT with the utmost precision, ensuring the most accurate results conceivable. Emotional support and counselling: We are cognizant of the emotional difficulties that may accompany fertility treatment and offer counselling services to aid you during this period.
PGT for Down syndrome is a powerful tool that allows couples to reduce the risk of having a baby with a genetic disorder before delivery. By selecting chromosomal normal embryos for transfer, PGT increases the chances of a successful pregnancy and a healthy baby. However, it is essential to consider the emotional, ethical, and financial aspects of PGT before deciding whether it is the right choice for you and your family.
At A4 Fertility Clinic, our team of experts is dedicated to providing comprehensive fertility services, including PGT for Down syndrome. We work closely with our patients to understand their unique needs and develop personalized treatment plans that optimize their chances of success. By offering state-of-the-art laboratory facilities, genetic counselling, and emotional support, we strive to provide the highest level of care on your journey to parenthood.
If you are considering PGT for Down syndrome, we encourage you to schedule a consultation with one of our fertility specialists to discuss your options and determine the best course of action for you and your family.
